MOTS-c — Mitochondrial Optimization Peptide
Fat metabolism • Insulin sensitivity • Cellular energy • Longevity signaling
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a mitochondria-encoded regulatory peptide that plays a central role in energy metabolism, glucose utilization, and cellular resilience. Unlike most peptides that act on the surface of cells, MOTS-c works inside the mitochondria, the engines that power every biological process.
As mitochondrial function declines with age, fatigue, metabolic slowdown, and insulin resistance increase. MOTS-c helps restore youthful metabolic signaling, making it one of the most advanced compounds in metabolic, longevity, and performance research.
In laboratory and clinical research, MOTS-c has been shown to support:
• Improved insulin sensitivity
• Enhanced glucose uptake
• Increased fat oxidation
• Higher mitochondrial output (ATP)
• Reduced metabolic inflammation
• Improved endurance and cellular stress resistance
MOTS-c allows cells to burn fuel more efficiently, shifting the body into a leaner, more energetic, and metabolically youthful state.
Why MOTS-c is different
MOTS-c does not suppress appetite or alter digestion —
it reprograms how cells use energy.
By activating AMPK and mitochondrial stress-response pathways, MOTS-c tells the body to:
• Burn fat instead of storing it
• Improve glucose utilization
• Increase cellular energy production
• Reduce metabolic fatigue
• Slow age-related decline
This makes MOTS-c one of the most promising peptides in fat-loss, endurance, and longevity-focused research.
Studied in research to support
• Obesity and insulin resistance
• Type-2 diabetes
• Fatigue and metabolic slowdown
• Exercise performance
• Aging and mitochondrial dysfunction
PHP™ Research Performance Standard
Our MOTS-c is supplied as a research-grade lyophilized peptide, produced in GMP-certified facilities and independently verified for:
✔ Identity
✔ Purity
✔ Potency
✔ Endotoxin levels
Because real performance begins at the cellular power plant.
Pure Science. Raw Power.